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Antipsychotic medication use and fracture: a case-control study
Behnaz Azimi Manavi1, Amanda L Stuart2, Julie A Pasco2,3,4,5
1IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Deakin University, Geelong, 3220, Australia. bazimimanavi@deakin.edu.au.
Scientific Reports
|August 22, 2023
Summary
Antipsychotic medication use significantly increases fracture risk in both men and women. This study suggests regular bone health monitoring for individuals taking antipsychotics is crucial.
Area of Science:
- Bone Health Research
- Pharmacological Studies
- Epidemiology
Background:
- Antipsychotic medications are linked to reduced bone mineral density and quality.
- Existing research suggests a potential association between antipsychotic use and skeletal fragility.
Purpose of the Study:
- To investigate the association between antipsychotic drug use and fracture risk.
- To analyze fracture risk in a population-based sample of Australian adults.
Main Methods:
- A case-control study design was employed, comparing individuals with fractures (cases) to those without (controls).
- Data on medication use, medical history, and lifestyle factors were collected via self-report.
- Multivariable binary logistic regression analysis was used to adjust for potential confounders.
Main Results:
- Antipsychotic use was associated with a 2.3-fold increased fracture risk in women and a 3.0-fold increased risk in men, after adjustments.
- The association remained significant even after excluding non-fragility fractures and participants with schizophrenia.
Conclusions:
- Antipsychotic use is a significant risk factor for fractures in both sexes.
- Regular bone health assessment is recommended for patients using antipsychotic medications.
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