The association between triglyceride glucose index and arthritis: a population-based study
Yuxin Yan1, Liyu Zhou1, Rui La1
1Department of Orthopedic Surgery, Orthopedic Institute, The First Affiliated Hospital, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, China.
Lipids in Health and Disease
|August 23, 2023
Summary
Higher triglyceride glucose (TyG) index values, a marker for insulin resistance, are linked to an increased risk of arthritis. This association was observed in US adults under 60 with normal weight and no diabetes.
Area of Science:
- Metabolic Health and Inflammatory Diseases
- Biomarker Research and Clinical Applications
Background:
- Insulin resistance is a known driver of inflammation.
- The triglyceride glucose (TyG) index is a validated biomarker for insulin resistance.
- The specific relationship between the TyG index and arthritis has not been previously investigated.
Purpose of the Study:
- To investigate the correlation between the TyG index and the prevalence of arthritis.
- To explore the potential of the TyG index as a predictor for arthritis risk.
Main Methods:
- An observational study utilizing National Health and Nutrition Examination Survey (NHANES) data from 2007-2018.
- Statistical analyses included weighted multivariable logistic regression, subgroup analysis, curve fit, and threshold effect analyses.
- A total of 14,817 participants were analyzed, with 4,191 diagnosed with arthritis.
Main Results:
- Higher TyG index values showed a significant positive correlation with arthritis risk (OR=1.15, 95% CI: 1.07-1.23) after full adjustment.
- The TyG index demonstrated an additive effect with age, BMI, and diabetes.
- A nonlinear relationship was identified with a breakpoint at 8.08 µmol/L.
Conclusions:
- The TyG index is positively associated with arthritis in specific demographics: US adults under 60, normal weight, and without diabetes.
- Further large-scale prospective studies are recommended to fully elucidate the role of the TyG index in arthritis pathogenesis.
Keywords:
ArthritisCross-sectional studyInsulin resistanceNational Health and Nutrition Examination SurveyTriglyceride glucose indexMore Related Videos
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