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Assessment of Child Anthropometry in a Large Epidemiologic Study
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Childhood obesity: Implications on adipose tissue dynamics and metabolic health

Ivonne Palacios-Marin1,2, Dolors Serra2,3, Josep C Jiménez-Chillarón1,4

  • 1Endocrinology Department, Institut de Recerca Sant Joan de Déu, Barcelona, Spain.

Obesity Reviews : an Official Journal of the International Association for the Study of Obesity
|August 23, 2023
PubMed

Insights

Childhood obesity poses lifelong health risks. Understanding how adipose tissue expands in children is crucial for preventing metabolic diseases later in life.

Area of Science:

  • Metabolic Health
  • Pediatric Endocrinology
  • Adipose Tissue Biology

Background:

  • Obesity is a primary risk factor for type 2 diabetes and cardiovascular diseases.
  • Childhood obesity often persists into adulthood, increasing long-term morbidity and mortality.
  • Adipose tissue expansion is key to obesity but its developmental mechanisms remain unclear.

Purpose of the Study:

  • To review white adipose tissue dynamics from development through lifetime expansion.
  • To elucidate mechanisms of adipose tissue growth in childhood obesity.
  • To highlight the impact of early-life adiposity on long-term metabolic health.

Main Methods:

  • Review of existing literature on adipose tissue development and expansion.
  • Analysis of cellular and lipid turnover in adipose tissue.
  • Examination of data from human studies and relevant mouse models.

Main Results:

  • Adipose tissue expansion is a complex process influenced by cellular and lipid turnover.
  • Mechanisms driving adipose tissue growth in childhood obesity require further investigation.
  • Early-life adiposity significantly impacts future metabolic health and adipose tissue function.

Conclusions:

  • Further research into childhood adipose tissue development is essential.
  • Understanding adipose tissue dynamics is critical for preventing obesity-related diseases.
  • Early intervention strategies may mitigate the lifelong health consequences of childhood obesity.

Keywords:
adipocyte turnoveradipose tissuechildhood obesitylipid turnover

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