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Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro
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Natural Polyphenols in Cancer Management: Promising Role, Mechanisms, and Chemistry

Prabhat Kumar Upadhyay1, Sonia Singh2, Vishal Kumar Vishwakarma3

  • 1Department of Pharmaceutical Science, Institute of Pharmaceutical Research, GLA University, Mathura, 281406, Uttar Pradesh, India.

Current Pharmaceutical Biotechnology
|August 23, 2023
PubMed
Abstract

Insights

Polyphenols show significant potential in preventing and treating cancers by targeting cellular mechanisms. Further research into their structure-activity relationships can lead to new natural anti-cancer therapies.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Oncology

Background:

  • Cancers develop rapidly and aggressively, impacting vital organs.
  • Current cancer treatments often target immune systems and intrinsic cellular processes.
  • Natural polyphenols demonstrate efficacy in cancer prevention and reversing disease progression.

Purpose of the Study:

  • To review the role of polyphenols in cancer prevention and treatment.
  • To explore the anti-metastatic properties of polyphenols.
  • To discuss structure-activity relationships (SARs) of polyphenols in anticancer activities.

Main Methods:

  • Literature search of electronic databases including Science Direct, Google Scholar, PubMed, and Scopus.
  • Focus on English language publications.
  • Analysis of reported anticancer activities and mechanisms of polyphenols.

Main Results:

  • Polyphenols exhibit anti-metastatic properties, crucial for cancer prevention.
  • These compounds modulate key signaling pathways like PI3K/Akt and TNF-induced pathways.
  • Structure-activity relationships (SARs) highlight the link between polyphenol structure and anticancer efficacy.

Conclusions:

  • Extensive research supports the anticancer potential of polyphenols.
  • SARs provide insights into developing effective chemotherapeutic agents from polyphenols.
  • Understanding mechanisms is vital for discovering novel natural anti-cancer products.
Keywords:
Tumour necrosis factorcancer preventionchemotherapy.polyphenolssignaling pathwaystructure-activity relationships

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