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Two new quassinoids from Simaba multiflora fruits.

C Moretti, S Bhatnagar, J C Beloeil

    Journal of Natural Products
    |May 1, 1986
    PubMed
    Summary
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    Two novel quassinoids were isolated from Simaba multiflora fruits. Their chemical structures were identified using advanced spectral data analysis, including NMR spectroscopy.

    Area of Science:

    • Natural Product Chemistry
    • Organic Chemistry
    • Pharmacognosy

    Background:

    • Simaba multiflora is a plant species known to produce bioactive compounds.
    • Quassinoids are a class of terpenoids with diverse pharmacological properties.
    • The isolation of new quassinoids can lead to the discovery of novel therapeutic agents.

    Purpose of the Study:

    • To isolate and characterize new quassinoid compounds from Simaba multiflora fruits.
    • To elucidate the chemical structures of the isolated compounds using spectroscopic methods.
    • To investigate the potential antileukemic activity of the identified quassinoids.

    Main Methods:

    • Extraction of compounds from Simaba multiflora fruits.
    • Purification of isolated compounds using chromatographic techniques.

    Related Experiment Videos

  • Structure determination using Nuclear Magnetic Resonance (NMR) spectroscopy, including 1H-13C 2-D chemical-shift correlation NMR, and other spectral data.

    • Main Results:

    • Two new quassinoids, 13,18-dehydro-6 alpha-senecioyloxychaparrin (4) and 12-dehydro-6 alpha-senecioyloxychaparrin (5), were successfully isolated.
    • The chemical structures of compounds 4 and 5 were fully elucidated using comprehensive spectral analysis.
    • Compound 4 was identified as an antileukemic quassinoid.

    Conclusions:

    • The study successfully identified two novel quassinoids from Simaba multiflora.
    • Advanced spectroscopic techniques, particularly 2D NMR, were crucial for the structural elucidation.
    • The findings contribute to the understanding of Simaba multiflora's chemical constituents and highlight a potential antileukemic compound.