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Iron Memory in E. coli.

Souvik Bhattacharyya¹, Nabin Bhattarai¹, Dylan M Pfannenstiel¹

¹Department of Molecular Biosciences and LaMontagne Center for Infectious Diseases, University of Texas at Austin; Austin, TX 78712.

Biorxiv : the Preprint Server for Biology

|August 23, 2023

Summary

Bacterial cells remember past experiences, like swarming, through cellular iron levels. This iron memory influences future swarming efficiency and is passed down through generations.

Keywords:

Antibiotics Biofilms E. coli Iron Memory Swarming Time-delay model

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Area of Science:

Microbiology
Bacterial Physiology
Cellular Memory

Background:

Bacterial decision-making processes are complex and influenced by environmental cues.
The role of cellular memory in bacterial adaptation and behavior remains largely unexplored.
Escherichia coli (E. coli) exhibits complex behaviors like swarming, which can be influenced by prior experiences.

Conclusions:

Prior swarming experience in E. coli is remembered via cellular iron levels, improving subsequent swarming.
This iron-dependent memory is heritable for several generations but can be artificially extended.
Cellular memory in bacteria is a dynamic process that integrates environmental stimuli and impacts diverse behaviors.