Related Experiment Video

Updated: Jul 18, 2025

Tuning the Contractility and Deformation Modes of Active Actin-Based Assemblies In Vitro: From Two-Dimensional Active Networks to Liquid Crystal Drops
06:48

Tuning the Contractility and Deformation Modes of Active Actin-Based Assemblies In Vitro: From Two-Dimensional Active Networks to Liquid Crystal Drops

Published on: July 11, 2025

52

Stiffness anisotropy coordinates supracellular contractility driving long-range myotube-ECM alignment

Nathaniel P Skillin1,2,3, Bruce E Kirkpatrick1,2,3, Katie M Herbert1

  • 1Department of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO, 80303, USA.

Biorxiv : the Preprint Server for Biology
|August 23, 2023
PubMed
Summary

Substrate stiffness anisotropy guides muscle stem cell alignment and tissue regeneration. This mechanical cue directs collective cell behavior, essential for skeletal muscle development and repair.

Keywords:
collective cell behaviorliquid crystalline polymer networksmechanosensingmyoblastsmyotube alignmentstiffness anisotropy

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