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Updated: Jul 18, 2025

Spatio-Temporal Manipulation of Small GTPase Activity at Subcellular Level and on Timescale of Seconds in Living Cells
10:27

Spatio-Temporal Manipulation of Small GTPase Activity at Subcellular Level and on Timescale of Seconds in Living Cells

Published on: March 9, 2012

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Spatiotemporal optical control of Gαq-PLCβ interactions

Sithurandi Ubeysinghe, Dinesh Kankanamge, Waruna Thotamune

    Biorxiv : the Preprint Server for Biology
    |August 23, 2023
    PubMed
    Summary

    Researchers developed Opto-dHTH, an optogenetic tool to control GαqGTP-PLCβ interactions. This innovation reveals that molecular competition between RhoGEFs and PLCβ dictates Gq-GPCR-driven cell migration.

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