The Relationship of Duffy Gene Polymorphism, High Sensitivity C-Reactive Protein, and Long-term Outcomes
Medrxiv : the Preprint Server for Health Sciences
|August 23, 2023
Summary
Duffy null status in Black adults is not linked to worse cardiovascular outcomes or higher mortality. Elevated hs-CRP levels in Duffy null individuals are likely due to linked CRP gene variants, not the Duffy null status itself.
Area of Science:
- Cardiovascular Science
- Genetics
- Population Health
Background:
- Black adults face higher all-cause mortality and worse cardiovascular outcomes.
- The Duffy chemokine receptor's absence in many Black adults has unclear clinical significance.
Approach:
- Investigated Duffy receptor status, hs-CRP, and cardiovascular outcomes in 4,307 Black participants from two longitudinal cohorts.
- Utilized SNP rs2814778 to define Duffy null and Duffy receptor positive status.
Key Points:
- Duffy null status was not independently associated with elevated hs-CRP after accounting for linked CRP alleles.
- Duffy null status did not independently predict higher all-cause mortality or secondary cardiovascular outcomes.
Conclusions:
- Increased hs-CRP in Duffy null individuals is attributed to co-inherited CRP alleles.
- Duffy null status is not associated with adverse cardiovascular outcomes in this cohort of Black participants.
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