Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hybridoma Technology01:31

Hybridoma Technology

14.9K
Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
Hybridoma Selection
Commonly used fusion techniques — electroporation,...
14.9K
Antibody Actions01:26

Antibody Actions

1.1K
Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
1.1K
Antibody Structure01:10

Antibody Structure

60.3K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
60.3K
Humoral Immune Responses01:36

Humoral Immune Responses

73.0K
Overview
73.0K
Antibody Structure and Classes01:25

Antibody Structure and Classes

957
Antibodies, also known as immunoglobulins, are produced by B cells in response to foreign substances, such as bacteria and viruses. These proteins are critical for recognizing and neutralizing these substances, protecting the body from potential harm.
The basic structure of an antibody consists of four protein chains: two identical heavy chains and two identical light chains. These chains are held together by disulfide bonds and other non-covalent interactions, forming a Y-shaped structure.
957
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

54
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
54

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bacterial Glutamine Synthetases as a Novel Metabolic Selection Marker to Improve CHO Cell Culture Performance Through Selection Stringency Modulation.

Biotechnology journal·2025
Same author

Deep learning-based design and experimental validation of a medicine-like human antibody library.

Briefings in bioinformatics·2025
Same author

Human antibody polyreactivity is governed primarily by the heavy-chain complementarity-determining regions.

Cell reports·2024
Same author

Biophysics of claudin proteins in tight junction architecture: Three decades of progress.

Biophysical journal·2024
Same author

Predicting deamidation and isomerization sites in therapeutic antibodies using structure-based <i>in silico</i> approaches.

mAbs·2024
Same author

Geometric Antibody Engineering Reveals the Spatial Factor on the Efficacy of Bispecific T Cell Engagers.

ACS chemical biology·2024

Related Experiment Video

Updated: Jul 18, 2025

Laboratory Scale Production and Purification of a Therapeutic Antibody
09:54

Laboratory Scale Production and Purification of a Therapeutic Antibody

Published on: January 24, 2017

17.5K

How can we discover developable antibody-based biotherapeutics?

Joschka Bauer1,2, Nandhini Rajagopal2,3, Priyanka Gupta2,3

  • 1Early Stage Pharmaceutical Development Biologicals, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach/Riss, Germany.

Frontiers in Molecular Biosciences
|August 23, 2023
PubMed
Summary
This summary is machine-generated.

Biopharmaceutical informatics integrates computation and experimentation to overcome challenges in antibody drug discovery. This approach accelerates the development of safe and effective antibody therapeutics for patients.

Keywords:
biopharmaceutical informaticsbiotherapeuticscomputational biophysicsdevelopabilitydrug discovery and developmentmachine learning

More Related Videos

Construction of Synthetic Phage Displayed Fab Library with Tailored Diversity
12:31

Construction of Synthetic Phage Displayed Fab Library with Tailored Diversity

Published on: May 1, 2018

13.8K
Scalable High Throughput Selection From Phage-displayed Synthetic Antibody Libraries
12:55

Scalable High Throughput Selection From Phage-displayed Synthetic Antibody Libraries

Published on: January 17, 2015

18.6K

Related Experiment Videos

Last Updated: Jul 18, 2025

Laboratory Scale Production and Purification of a Therapeutic Antibody
09:54

Laboratory Scale Production and Purification of a Therapeutic Antibody

Published on: January 24, 2017

17.5K
Construction of Synthetic Phage Displayed Fab Library with Tailored Diversity
12:31

Construction of Synthetic Phage Displayed Fab Library with Tailored Diversity

Published on: May 1, 2018

13.8K
Scalable High Throughput Selection From Phage-displayed Synthetic Antibody Libraries
12:55

Scalable High Throughput Selection From Phage-displayed Synthetic Antibody Libraries

Published on: January 17, 2015

18.6K

Area of Science:

  • Biopharmaceutical Informatics
  • Antibody Drug Discovery
  • Computational Biology

Background:

  • Antibody-based biotherapeutics represent a successful but challenging pharmaceutical class.
  • Significant hurdles exist in the research and development (R&D) of these complex drugs.

Purpose of the Study:

  • To propose biopharmaceutical informatics as a framework to address R&D challenges.
  • To advocate for integrating computation and experimentation throughout biologic drug discovery.
  • To consider drug developability early in the discovery phase.

Main Methods:

  • Review of computational approaches for antigen optimization and immune response.
  • Analysis of in silico antibody sequence generation and virtual screening.
  • Assessment of computational methods for lead candidate identification and affinity maturation.

Main Results:

  • Computational advances enable precise disease concept formulation and target identification.
  • Emerging computational methods facilitate de novo and epitope-specific antibody design.
  • Virtual screening and computational assessment aid in discovering and optimizing antibody binders.

Conclusions:

  • Biopharmaceutical informatics offers opportunities to overcome limitations in antibody R&D.
  • Integrating computational strategies enhances candidate selection and developability.
  • Adoption of this framework can accelerate the delivery of affordable, effective biotherapeutics.