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Related Concept Videos

Cerebellum: Anatomical Regions01:17

Cerebellum: Anatomical Regions

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The cerebellum, also known as the "little brain," is located in the posterior cranial fossa, inferior to the tentorium cerebelli and dorsal to the brainstem. It plays a significant role in motor control, coordination, and proprioception.
Cerebellar Structure
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Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...
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REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
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Neural Regulation01:37

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Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
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Related Experiment Video

Updated: Jul 18, 2025

Author Spotlight: Deciphering the Role of ATM in Ataxia-Telangiectasia and the Associated Cerebellar Degeneration
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Author Spotlight: Deciphering the Role of ATM in Ataxia-Telangiectasia and the Associated Cerebellar Degeneration

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BDNF and Cerebellar Ataxia.

Robert Lalonde1, Magali Hernandez1,2, Catherine Strazielle1,2

  • 1Université de Lorraine, Laboratoire Stress, Immunité, Pathogènes EA 7300, Campus Santé, 9 avenue de la Forêt de Haye, 54500 Vandoeuvre-les-Nancy, France.

Current Drug Research Reviews
|August 23, 2023
PubMed
Summary
This summary is machine-generated.

Brain-derived neurotrophic factor (BDNF) shows promise for treating cerebellar neurodegeneration by replacing diminished BDNF levels. This study explores its efficacy in various cerebellar conditions, including those with normal BDNF levels or combined brain region damage.

Keywords:
Friedreich’s ataxiaNeurotrophincerebellar developmentcerebellar mutantsrotarod.spinocerebellar ataxia

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Neurodegenerative diseases affecting the cerebellum often exhibit reduced levels of brain-derived neurotrophic factor (BDNF) or its receptor, TrkB.
  • BDNF replacement therapy is a potential strategy to counteract cerebellar degeneration.

Purpose of the Study:

  • To evaluate the therapeutic effectiveness of BDNF in cerebellar pathologies.
  • To investigate BDNF efficacy in conditions with normal BDNF levels and in cases involving combined cerebellar and basal ganglia damage.

Main Methods:

  • Review of experimental evidence from various mouse and rat models of cerebellar degeneration, including transgenic and gene-knockout models.
  • Analysis of studies involving lentivector-mediated gene delivery and BDNF-overexpressing transgenic lines.

Main Results:

  • BDNF signaling has demonstrated efficacy in counteracting cerebellar degeneration and sensorimotor deficits in multiple preclinical models.
  • Evidence suggests BDNF may be beneficial in conditions characterized by diminished BDNF levels.

Conclusions:

  • BDNF shows therapeutic potential for cerebellar neurodegeneration, particularly when BDNF levels are reduced.
  • Further investigation is warranted to determine BDNF's effectiveness in cerebellar pathologies with normal BDNF levels and in complex cases affecting multiple brain regions.