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Primary gastrointestinal lymphomas: a classification of 66 cases
Cancer
|May 1, 1979
Summary
This study classified 66 gastrointestinal lymphomas, finding 50% originated from histiocytes and 41% from lymphocytes. Reliable criteria were developed to distinguish between these origins for better lymphoma classification.
Area of Science:
- Gastrointestinal Pathology
- Hematopathology
- Oncology
Background:
- Gastrointestinal lymphomas are diverse, requiring precise classification.
- Distinguishing between histiocytic and lymphocytic origins is crucial for accurate diagnosis.
Purpose of the Study:
- To classify primary gastrointestinal lymphomas.
- To establish reliable criteria for differentiating histiocytic from lymphocytic lymphomas.
- To investigate the characteristics of histiocyte-derived gastrointestinal lymphomas.
Main Methods:
- Analysis of 66 primary gastrointestinal lymphoma cases.
- Utilized routine histology, resin-embedded sections, and immunohistochemistry.
- Developed specific morphologic and immunohistochemical criteria for cell origin determination.
Main Results:
- Established criteria identified malignant histiocytes by pleomorphic nuclei, abundant cytoplasm, and phagocytosis.
- Histiocyte-derived lymphomas comprised 50% of cases (33% malignant histiocytosis of the intestine, 17% histiocytic lymphoma).
- Lymphocyte-derived lymphomas accounted for 41% of cases; 5% were unclassified or Hodgkin's disease.
Conclusions:
- Histiocytic origin is a significant component of primary gastrointestinal lymphomas.
- The developed criteria aid in distinguishing histiocytic from lymphocytic gastrointestinal lymphomas.
- Further research into the role of histiocytes in gastrointestinal mucosa is warranted.