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Platinum-based nanodendrites as glucose oxidase-mimicking surrogates
Jose I Garcia-Peiro1,2,3,4, Javier Bonet-Aleta1,2,3,4, Maria L Tamayo-Fraile1,2
1Instituto de Nanociencia y Materiales de Aragon (INMA); CSIC-Universidad de Zaragoza, Campus Rio Ebro, Edificio I+D, C/Poeta Mariano Esquillor, s/n, 50018, Zaragoza, Spain. jlhueso@unizar.es.
Nanoscale
|August 23, 2023
Summary
Platinum nanodendrites effectively mimic enzymes for glucose conversion. These novel nanozymes convert glucose to gluconolactone with high selectivity, offering potential applications in nanocatalytic medicine and biotechnology.
Area of Science:
- Nanomaterials Science
- Catalysis
- Biotechnology
- Nanomedicine
Background:
- Glucose conversion is vital in biotechnology and nanocatalytic medicine for producing valuable chemicals and targeting cancer cells via glucose starvation in the tumor microenvironment (TME).
- Current methods using glucose oxidase (GOx) enzymes face limitations like degradation, poor recyclability, and strict reaction conditions.
- Gold-based nanomaterials have been explored as alternatives but suffer from low selectivity, oxygen dependency, and size-related issues in liquid-phase reactions.
Purpose of the Study:
- To develop novel inorganic catalytic surrogates for glucose conversion.
- To synthesize platinum-based nanodendrites as enzyme-mimicking nanozymes.
- To evaluate their efficiency and selectivity in converting glucose to gluconolactone.
Main Methods:
- Synthesis of platinum-based nanodendrites.
- Evaluation of glucose conversion activity and selectivity.
- Application of Michaelis-Menten and Lineweaver-Burk models to study enzymatic behavior.
- Determination of glucose turnover rates for Pt and Pt-Au nanodendrites.
Main Results:
- Platinum-based nanodendrites demonstrated high selectivity (>85%) for converting glucose into gluconolactone.
- These Pt-based nanozymes exhibit enzyme-like kinetics, analyzed using established kinetic models.
- Competitive glucose turnover rates were determined for Pt and Pt-Au nanodendrites.
Conclusions:
- Platinum-based nanodendrites serve as effective inorganic enzyme mimics for glucose conversion.
- The developed nanozymes offer a promising alternative to traditional enzymes and gold-based catalysts.
- These findings highlight the potential of Pt nanodendrites in applications requiring selective glucose conversion, including TME modulation in cancer therapy.
