The use of ICSI in ART: evidence for practice

Area of Science:

• Reproductive Medicine
• Embryology
• Genetics

Background:

• Intra-cytoplasmic sperm injection (ICSI) is a key technique in assisted reproductive technology (ART).
• Evidence supporting ICSI's safety and efficacy requires regular review and guideline updates.
• Clinical decisions regarding ICSI necessitate clear, evidence-based recommendations.

Purpose of the Study:

• To review the evidence on the safety and efficacy of intra-cytoplasmic sperm injection (ICSI).
• To establish evidence-based clinical and laboratory guidelines for ICSI use in ART.
• To address the comparative evidence of ICSI versus conventional in vitro fertilization (cIVF) and associated risks.

Main Methods:

• Systematic review of existing scientific literature on ICSI.
• Development of clinical and laboratory guidelines based on evidence synthesis.
• Analysis of data pertaining to ICSI efficacy, safety, and supplementary ART techniques.

Main Results:

• Evidence supports the use of ICSI in specific infertility contexts.
• Guidelines address the comparative effectiveness of ICSI against conventional IVF.
• Potential risks associated with ICSI procedures are identified and discussed.

Conclusions:

• ICSI guidelines provide a framework for its application in ART services.
• The guidelines emphasize an evidence-based approach to ICSI, considering patient-specific factors.
• This article serves as a recommendation, not a rigid standard, allowing for tailored patient management.