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Related Concept Videos

Cell Migration01:19

Cell Migration

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Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
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Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

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A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
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Role of Myosin in Cell Migration01:18

Role of Myosin in Cell Migration

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Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
Myosin II  is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction....
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Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

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Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
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Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

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The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
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Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

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In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
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Updated: Jul 18, 2025

Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration
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Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration

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Cell-matrix and cell-cell interaction mechanics in guiding migration.

Hoang Anh Le1, Roberto Mayor1

  • 1Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, U.K.

Biochemical Society Transactions
|August 23, 2023
PubMed
Summary

Tissue physical properties like stiffness and topology significantly influence cell migration. This review highlights the underappreciated role of cell-cell interactions in modulating these physical cues and affecting cell movement.

Keywords:
cell migrationcell–cell interactionsmechanobiologystiffnesstissue mechanics

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Area of Science:

  • Biophysics
  • Cell Biology
  • Tissue Engineering

Background:

  • Physical properties of tissue are critical regulators of cell behaviors, especially cell migration.
  • While extracellular matrix mechanics are well-studied, the impact of cellular components on tissue physical properties and cell migration remains less understood.

Approach:

  • This mini-review synthesizes current knowledge on tissue physical properties influencing cell migration.
  • Focuses on the roles of tissue stiffness and topology.
  • Emphasizes the significance of cell-cell interactions in mediating these effects.

Key Points:

  • Tissue stiffness and topology are key physical cues impacting cell migration.
  • Cell-cell interactions play a crucial, yet often overlooked, role in modulating tissue physical properties.
  • Understanding these cellular contributions is vital for comprehending tissue development and disease.

Conclusions:

  • Cellular components significantly influence tissue physical properties that regulate cell migration.
  • Further research into cell-cell interactions and their impact on tissue mechanics is warranted.
  • This knowledge can advance fields like regenerative medicine and cancer biology.