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A Primer on Gene Editing: What Does It Mean for Pathologists?

Allison Cushman-Vokoun1, Ryan J Schmidt2,3, Matthew Charles Hiemenz4

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Gene editing therapies offer transformative potential but require careful consideration of risks and ethics. Pathologists must engage with these advancements to ensure proper implementation in diagnostics and patient care.

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Area of Science:

  • Biotechnology
  • Genetics
  • Medical Science

Background:

  • Gene editing technologies are advancing rapidly for treating oncology, inherited, and infectious diseases.
  • These therapies, rooted in natural principles, present significant considerations including risks, cost, and ethical questions.

Purpose of the Study:

  • To educate pathologists on gene editing technologies, their indications, and risks.
  • To inform pathologists about regulatory and practical issues impacting laboratory practice.
  • To advocate for pathologist involvement in discussions regarding gene editing therapies.

Main Methods:

  • Convened a Gene Editing Workgroup comprising pathologists from diverse backgrounds.
  • Conducted literature reviews and multiple discussions to identify knowledge gaps.
  • Developed an educational paper to stimulate pathologist engagement in gene editing implementation.

Main Results:

  • Identified potential gaps in pathologists' understanding of gene editing.
  • Highlighted topics impacting pathology and laboratory medicine related to gene editing.
  • Summarized key information to facilitate pathologist roles as stakeholders.

Conclusions:

  • Gene editing therapy is a complex, transformative field in medicine.
  • This article serves as an introductory resource for pathologists.
  • It aims to aid pathologists in discussions and adapting practices for gene editing.