Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

38.4K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.4K
Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

6.4K
Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
6.4K
Bone Structure01:55

Bone Structure

48.7K
Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
48.7K
Bone as Supporting Connective Tissue01:23

Bone as Supporting Connective Tissue

3.5K
Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts—...
3.5K
Fractures: Bone Repair01:27

Fractures: Bone Repair

3.3K
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
3.3K
Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

4.6K
Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
4.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Treatment of Severe Periodontitis using Exosome-Mediated Combination Therapies: A Retrospective Cohort Study.

Oral health & preventive dentistry·2026
Same author

Use of Liquid Platelet-Rich Fibrin (Liquid PRF) as a New, Effective Regenerative Treatment for Steroid-Induced Subcutaneous and Dermal Atrophy.

Cureus·2026
Same authorSame journal

Understanding exosomes in regenerative dentistry.

Periodontology 2000·2026
Same author

Efficacy of H-PRF Bone Block Versus DBBM in Transcrestal Sinus Floor Elevation: A Retrospective Cohort Study.

Clinical implant dentistry and related research·2026
Same author

Understanding exosomes in diabetic wound healing.

Periodontology 2000·2026
Same author

Understanding exosomes in facial esthetics and skin aging.

Periodontology 2000·2026
Same journal

Effects of non-surgical periodontal therapy on intrabony periodontal defects at different re-evaluation time points: A systematic review of randomized controlled trials and clinical recommendations.

Periodontology 2000·2026
Same journal

Improving periodontal regeneration outcomes with hyaluronic acid: A systematic review and meta-analysis.

Periodontology 2000·2026
Same journal

Does adherence to supportive periodontal care lower the risk of caries and related tooth loss? A systematic review and meta-analysis.

Periodontology 2000·2026
Same journal

Long-term stability of periodontal plastic surgery featuring traditional autogenous graft and coronally advanced flap alone.

Periodontology 2000·2026
Same journal

Peri-implantitis-Is it mainly a clinician-initiated complication of implant therapy?

Periodontology 2000·2026
See all related articles

Related Experiment Video

Updated: Jul 18, 2025

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
06:53

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

2.8K

Optimized bone grafting.

Richard J Miron1

  • 1Department of Periodontology, University of Bern, Bern, Switzerland.

Periodontology 2000
|August 23, 2023
PubMed
Summary
This summary is machine-generated.

This review explores bone grafting materials, introducing novel nonresorbable bone allografts (NRBAs). NRBAs offer human biocompatibility and xenograft-like stability, simplifying bone grafting procedures in periodontology and implant dentistry.

Keywords:
anorganic bovine bone mineraldeproteinized bovine bone mineralextraction site managementnonresorbable bone allograft

More Related Videos

Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts
13:16

Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts

Published on: December 22, 2015

11.5K
Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry
11:20

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry

Published on: March 29, 2018

7.6K

Related Experiment Videos

Last Updated: Jul 18, 2025

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
06:53

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

2.8K
Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts
13:16

Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts

Published on: December 22, 2015

11.5K
Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry
11:20

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry

Published on: March 29, 2018

7.6K

Area of Science:

  • Periodontology and Oral Surgery
  • Biomaterials Science
  • Regenerative Medicine

Background:

  • Bone grafting is crucial in oral surgery for bone void regeneration.
  • Autogenous bone is ideal but limited; allografts and xenografts are common alternatives.
  • Xenografts, sintered at high temperatures, offer slow resorption and stability, often combined with other grafts.

Purpose of the Study:

  • To review regenerative and biomechanical properties of bone graft classes.
  • To highlight clinical applications of different bone grafts.
  • To introduce novel nonresorbable bone allografts (NRBAs) and their potential.

Main Methods:

  • Literature review of bone graft regenerative and biomechanical properties.
  • Discussion of clinical applications: extraction sites, contour augmentation, sinus grafting, vertical/horizontal augmentation.
  • Introduction of high-temperature sintering for producing NRBAs.

Main Results:

  • Xenografts offer stability but have cross-species concerns.
  • Novel NRBAs provide human biocompatibility and xenograft-like nonresorbability.
  • NRBAs allow premixing with standard allografts, overcoming regulatory hurdles for xenograft combinations.

Conclusions:

  • NRBAs simplify bone grafting by enabling customized premixtures without regulatory restrictions.
  • This innovation offers optimized ratios for specific indications, potentially reducing costs.
  • The development of NRBAs promises simplified and optimized bone grafting in periodontology and implant dentistry.