Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

MicroRNAs01:22

MicroRNAs

3.0K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Circulating microRNA profiles associated with tick bite and debilitating symptom complexes attributed to ticks (DSCATT).

Scientific reports·2026
Same author

Meta-analysis of functional genomics studies reveals conserved cellular pathways required by viruses of pandemic concern.

Access microbiology·2026
Same author

Development and validation of a serum microRNA biomarker panel for bovine Johne's disease.

Journal of dairy science·2026
Same author

2'-O-Methyl-guanosine RNA fragments antagonize TLR7 and TLR8 to limit autoimmunity.

Nature immunology·2026
Same author

Single-cell transcriptomics uncovers key immune drivers of vaccine efficacy in cattle.

BMC genomics·2025
Same author

Genome-wide analysis of host-encoded microRNAs modulating SARS-CoV-2 infection.

Scientific data·2025

Related Experiment Video

Updated: Jul 18, 2025

MicroRNA-based Regulation of Picornavirus Tropism
09:05

MicroRNA-based Regulation of Picornavirus Tropism

Published on: February 6, 2017

7.6K

Profiling Host MicroRNA Responses to Henipavirus Infection.

Ryan J Farr1, Sudeep Dahal1, Leon Tribolet1

  • 1CSIRO Australian Animal Health Laboratory, Health & Biosecurity, Geelong, VIC, Australia.

Methods in Molecular Biology (Clifton, N.J.)
|August 23, 2023
PubMed
Summary

Henipavirus infections can spread silently during long incubation periods. Researchers are developing microRNA (miR) assays to detect these infections early using host biomarkers.

Keywords:
BiomarkerDiagnosticHenipavirusmicroRNA

More Related Videos

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
11:28

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus

Published on: October 7, 2011

11.1K
High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions
14:58

High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions

Published on: March 5, 2022

4.3K

Related Experiment Videos

Last Updated: Jul 18, 2025

MicroRNA-based Regulation of Picornavirus Tropism
09:05

MicroRNA-based Regulation of Picornavirus Tropism

Published on: February 6, 2017

7.6K
Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
11:28

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus

Published on: October 7, 2011

11.1K
High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions
14:58

High-Throughput Transcriptome Analysis for Investigating Host-Pathogen Interactions

Published on: March 5, 2022

4.3K

Area of Science:

  • Virology
  • Biomarker Discovery
  • Molecular Biology

Background:

  • Henipavirus infections pose a significant public health risk due to asymptomatic transmission.
  • Early detection of henipavirus is crucial for preventing outbreaks and managing disease.
  • Host-derived biomarkers are being investigated for early disease identification.

Purpose of the Study:

  • To develop a methodology for assaying host microRNAs (miRs) as potential biomarkers for early henipavirus detection.
  • To explore the utility of miRs in understanding henipavirus infection pathogenesis.

Main Methods:

  • Development of a methodology for assaying host microRNAs (miRs).
  • Analysis of miRs responsive during early-stage henipavirus infection.
  • Profiling of miRs to gain insights into cellular and immune pathways.

Main Results:

  • Demonstrated a methodology for assaying host miRs.
  • Identified miRs that are responsive during early henipavirus infection.
  • MiRNA profiling provided insights into disease pathogenesis.

Conclusions:

  • Host microRNAs show promise as biomarkers for early henipavirus detection.
  • MiRNA profiling aids in understanding the cellular and immune responses to henipavirus infection.
  • This approach can contribute to improved diagnostics and therapeutic strategies for henipavirus diseases.