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Current development of pyrazole-azole hybrids with anticancer potential

Shu Zhang1, Yun Ye2, Qiang Zhang1

  • 1Hubei Key Laboratory of Pollution Damage Assessment & Environmental Health Risk Prevention & Control, Hubei Provincial Academy of Eco-Environmental Sciences, Wuhan, Hubei, 430000, PR China.

Future Medicinal Chemistry
|August 23, 2023
PubMed

Insights

Novel pyrazole-azole hybrids show promise as anticancer agents, addressing challenges in chemotherapy. This review highlights recent advances and structure-activity relationships to guide the development of more effective cancer therapeutics.

Area of Science:

  • Medicinal Chemistry
  • Oncology
  • Drug Discovery

Background:

  • Multidrug resistance is a major challenge in cancer chemotherapy, necessitating new therapeutic agents.
  • Azole compounds, especially pyrazoles, possess diverse biological activities, including anticancer potential.
  • Azole moieties are present in several approved anticancer drugs, indicating their significance in drug design.

Purpose of the Study:

  • To review recent advancements in pyrazole-azole hybrids with demonstrated anticancer activity.
  • To discuss structure-activity relationships (SAR) of these compounds.
  • To aid in the rational design of novel anticancer drug candidates.

Main Methods:

  • Literature search for articles published from 2018 to present.
  • Analysis of reported anticancer activities of pyrazole-azole hybrids.
  • Evaluation of SAR based on structural modifications and their impact on efficacy.

Main Results:

  • Identification of various pyrazole-azole hybrids exhibiting significant in vitro and in vivo anticancer effects.
  • Correlation of specific structural features with enhanced potency and selectivity against cancer cell lines.
  • Insights into mechanisms of action for promising compounds.

Conclusions:

  • Pyrazole-azole hybrids represent a promising scaffold for developing novel anticancer drugs.
  • Understanding SAR is crucial for optimizing the design of these hybrids.
  • Further research is warranted to translate these findings into clinical applications.
Keywords:
anticancerazolehybridimidazoleisoxazolemechanism of actionoxazolepyrazolestructure–activity relationshipthiazoletriazole

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