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Quantitative and Multiplexed Chopper-Based Time-Gated Imaging for Bioanalysis on a Smartphone.

Sahil S Kanani1, Hsin-Yun Tsai1, W Russ Algar1

  • 1Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, British Columbia V6T 1Z1, Canada.

Analytical Chemistry
|August 23, 2023
PubMed
Summary

This study introduces a 3D-printed smartphone device for time-gated (TG) photoluminescence (PL) imaging. This portable platform enables sensitive diagnostics by eliminating background noise, paving the way for advanced point-of-care diagnostics (POCDs).

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Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Optical Imaging

Background:

  • Smartphones are increasingly used for point-of-care diagnostics (POCDs).
  • Time-gated (TG) photoluminescence (PL) measurements offer sensitive detection by minimizing background noise.
  • Long-lived PL emitters, like luminescent lanthanide complexes (LLCs), are crucial for TG-PL.

Purpose of the Study:

  • To develop a portable, smartphone-based device for time-gated (TG) photoluminescence (PL) imaging.
  • To demonstrate the feasibility of TG PL imaging for point-of-care diagnostics (POCDs) using a smartphone platform.

Main Methods:

  • A portable, 3D-printed device with a double-chopper design was created for smartphone-based TG PL imaging.
  • The device utilizes the smartphone's camera and precisely controlled choppers to achieve time-gating.
  • Experiments involved imaging LLCs and evaluating background rejection from various samples.

Main Results:

  • The device successfully performed quantitative TG PL imaging of terbium(III) and europium(III) LLCs.
  • It demonstrated effective rejection of short-lived PL background from serum and tissue phantoms.
  • Capabilities included spectral and temporal multiplexing, a TG-FRET assay, and cell imaging.

Conclusions:

  • This work presents the first smartphone-based demonstration of TG PL imaging capabilities.
  • The developed device provides a foundational platform for advancing POCD methods using TG PL imaging.
  • This technology holds promise for sensitive, low-background diagnostic applications in resource-limited settings.