Distinguishing subtypes of spinal locomotor neurons to inform circuit function and dysfunction

Locomotion is a complex motor task executed by spinal neurons. Given the diversity of spinal cord neurons, linking neuronal cell type to function is a challenge. Molecular identification of broad spinal interneuronal classes provided a great advance. Recent studies have used other classifiers, including location, electrophysiological properties, and connectivity, in addition to gene profiling, to narrow the acuity with which groups of neurons can be related to specific functions. However, there are also functional populations without a clear identifier, as exemplified by rhythm generating neurons. Other considerations, including experience or plasticity, add a layer of complexity to the definition of functional subpopulations of spinal neurons, but spinal cord injury may provide insight.