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Updated: Jul 18, 2025

Metabolic Glycoengineering of Sialic Acid Using N-acyl-modified Mannosamines
Published on: November 25, 2017
Advances in sulfonated modification and bioactivity of polysaccharides
Chunmei Niu1, Yanan Liu1, Yuxuan Yang1
1Hebei Key Laboratory of Flexible Functional Materials, School of Materials Science and Engineering, Hebei University of Science and Technology, Shijiazhuang 050000, China.
Abstract:
Polysaccharides, as biological macromolecules, are widely found in plants, animals, fungi, and bacteria and exhibit various biological activities. However, many natural polysaccharides exhibit low or non-existent biological activities because of their high molecular weights and poor water solubility, limiting their application in many fields. Sulfonation is one of the most effective chemical modification methods to improve physicochemical properties and biological activities of natural polysaccharides or even impart natural polysaccharides with new biological activities. Therefore, sulfonated polysaccharides have attracted increasing attention because of their antioxidant, anticoagulant, antiviral, and immunomodulatory properties. This paper reviews the recent advances in the sulfonation of polysaccharides, including preparation, characterization, and biological activities of sulfonated polysaccharides, and provides a theoretical basis for wide applications of sulfonated polysaccharides.
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