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Advances in sulfonated modification and bioactivity of polysaccharides
Chunmei Niu1, Yanan Liu1, Yuxuan Yang1
1Hebei Key Laboratory of Flexible Functional Materials, School of Materials Science and Engineering, Hebei University of Science and Technology, Shijiazhuang 050000, China.
International Journal of Biological Macromolecules
|August 23, 2023
Summary
Sulfonation enhances natural polysaccharides, improving their properties and biological activities like antioxidant and antiviral effects. This modification opens doors for wider applications of these valuable biomolecules.
Area of Science:
- Biochemistry and Macromolecular Science
- Chemical Modification of Biopolymers
Background:
- Natural polysaccharides are abundant biomacromolecules with diverse biological activities.
- High molecular weight and poor solubility limit the application of many natural polysaccharides.
- Chemical modification, particularly sulfonation, can overcome these limitations.
Purpose of the Study:
- To review recent advances in the sulfonation of polysaccharides.
- To explore the preparation, characterization, and biological activities of sulfonated polysaccharides.
- To provide a theoretical basis for the broad application of sulfonated polysaccharides.
Main Methods:
- Chemical modification of natural polysaccharides via sulfonation.
- Characterization of the physicochemical properties of modified polysaccharides.
- Evaluation of the biological activities of sulfonated polysaccharides.
Main Results:
- Sulfonation significantly improves the physicochemical properties (e.g., solubility) of natural polysaccharides.
- Sulfonated polysaccharides exhibit enhanced biological activities, including antioxidant, anticoagulant, antiviral, and immunomodulatory effects.
- The modification process can also impart novel biological activities.
Conclusions:
- Sulfonation is a key strategy for enhancing the utility of natural polysaccharides.
- Sulfonated polysaccharides demonstrate significant potential for various biomedical and industrial applications.
- Further research into sulfonation techniques will broaden the application scope of these biomacromolecules.
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