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Cell Population Analyses During Skin Carcinogenesis
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A Roadmap for a Consensus Human Skin Cell Atlas and Single-Cell Data Standardization.

Axel A Almet1, Hao Yuan2, Karl Annusver2

  • 1Department of Mathematics, University of California, Irvine, Irvine, California, USA; NSF-Simons Center for Multiscale Cell Fate Research, University of California, Irvine, Irvine, California, USA.

The Journal of Investigative Dermatology
|August 23, 2023
PubMed
Summary

Researchers are building a Human Skin Cell Atlas to map skin cell types and molecular signatures. This comprehensive resource will aid dermatological discovery by addressing data gaps and technical challenges.

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Area of Science:

  • Dermatology
  • Genomics
  • Bioinformatics

Background:

  • Single-cell technologies are crucial for dermatology research.
  • A comprehensive reference atlas for normal human skin cell types and molecular signatures is currently lacking.
  • Broad acceptance of a skin atlas requires multi-investigator participation.

Purpose of the Study:

  • To establish a consensus Human Skin Cell Atlas as a foundational resource.
  • To outline a roadmap for constructing a comprehensive skin cell atlas.
  • To identify and address challenges in creating a representative skin atlas.

Main Methods:

  • Assembled a Skin Biological Network within the Human Cell Atlas project.
  • Defined drivers of skin diversity for dataset selection.
  • Identified practical hurdles in skin sampling, tissue processing, and computational analysis.

Main Results:

  • Outlined considerations for dataset selection to capture skin diversity.
  • Highlighted potential data gaps and biases from sampling and processing.
  • Proposed strategies to minimize batch effects and improve cell type representation.

Conclusions:

  • The Human Skin Cell Atlas (Atlas 1.0) aims to provide a standardized reference for skin biology.
  • Addressing technical and sampling challenges is key to atlas accuracy and utility.
  • This atlas will facilitate new discoveries in basic and translational dermatology.