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Novel Atomic Force Microscopy Based Biopanning for Isolation of Morphology Specific Reagents against TDP-43 Variants in Amyotrophic Lateral Sclerosis
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miRNA profiling as a complementary diagnostic tool for amyotrophic lateral sclerosis.

Jack Cheng1,2, Wen-Kuang Ho1, Bor-Tsang Wu3

  • 1Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung, 40402, Taiwan.

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|August 23, 2023
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Summary

This study developed a genetic diagnostic rule for amyotrophic lateral sclerosis (ALS) using microRNA (miRNA) profiling. The rule shows potential for early ALS recognition and diagnosis.

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Area of Science:

  • Neuroscience
  • Genetics
  • Molecular Biology

Background:

  • Amyotrophic lateral sclerosis (ALS) is a prevalent motor neuron disease with complex genetics.
  • A definitive diagnostic test for ALS is currently lacking.
  • MicroRNAs (miRNAs) are implicated in ALS pathogenesis.

Purpose of the Study:

  • To develop and validate a miRNA-based diagnostic rule for ALS.
  • To investigate the pathogenic role of specific miRNAs in ALS.
  • To explore miRNA profiling as a complementary diagnostic tool for ALS.

Main Methods:

  • A miRNA profiling dataset of 253 ALS and 103 control samples was utilized.
  • A diagnostic rule was developed using 80% of the data and validated on the remaining 20%.
  • The rule identified specific miRNAs including miR-205-5p, miR-206, and others.

Main Results:

  • The developed diagnostic rule achieved an 82% true positive rate and 73% true negative rate on unseen samples.
  • Identified miRNAs target genes within the PI3K-Akt and ALS pathways.
  • Key targeted genes include BCL2, NEFH, and OPTN.

Conclusions:

  • miRNA profiling demonstrates potential as a complementary diagnostic tool for ALS.
  • This approach may aid in the early recognition and diagnosis of ALS.
  • The findings shed light on the role of miRNAs in ALS pathogenesis.