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[Toxicity studies of VP 16-213 (VI)--Antigenicity in guinea pigs]

N Takahashi, S Kawano, H Kohmura

The Journal of Toxicological Sciences

|April 1, 1986

Abstract:

VP 16-213 (etoposide, abbr. to VP), an oncostatic drug, and VP-protein conjugates were examined for their antigenic properties using male Hartley guinea pigs. The results of systemic anaphylaxis test, passive cutaneous anaphylaxis test, passive hemagglutination test and Schultz-Dale reaction revealed that VP possessed neither antigenic nor haptenic properties. The dose levels of VP employed in the present experiment were confirmed not to suppress immune reactions.

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