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Tannins in cancer prevention and therapy

Robert Kleszcz1, Aleksandra Majchrzak-Celińska1, Wanda Baer-Dubowska1

  • 1Department of Pharmaceutical Biochemistry, Poznan University of Medical Sciences, Poznań, Poland.

British Journal of Pharmacology
|August 24, 2023
PubMed

Insights

Tannins show significant potential in cancer prevention and therapy by targeting key cellular pathways. Further research and clinical trials are needed to explore their use as chemosensitizers and in drug delivery systems.

Area of Science:

  • Natural Products Chemistry
  • Cancer Biology
  • Pharmacology

Background:

  • Tannins are polyphenolic compounds with demonstrated anticancer properties.
  • Over 30 years of research highlight their ability to impact cancer development pathways.

Purpose of the Study:

  • To review the anti-cancer mechanisms of tannins.
  • To explore their potential as chemosensitizers and in drug delivery.
  • To discuss new applications like inhibiting epithelial-to-mesenchymal transition and modulating cancer cell metabolism.

Main Methods:

  • Literature review of studies on tannin's anti-cancer activities.
  • Analysis of recent findings on novel anti-carcinogenic mechanisms.
  • Examination of physicochemical properties for nanovehicle formation and cell isolation.

Main Results:

  • Tannins target multiple cancer-related cellular pathways.
  • New mechanisms include inhibiting EMT, reducing cancer stem cells, and modulating metabolism.
  • Tannic acid's properties are useful for nanocarriers and isolating circulating tumor cells.

Conclusions:

  • Tannins possess broad potential in cancer chemoprevention and therapy.
  • Further investigation into their roles as chemosensitizers and in advanced drug delivery is warranted.
  • Clinical trials are essential to validate the therapeutic efficacy of tannins in cancer treatment.
Keywords:
cancer cellschemosensitizationellagic acidepigallocatechin gallatenanomedicinetannic acidtannins

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