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A Comprehensive Insight and Mechanistic Understanding of the Lipidomic Alterations Associated With DCM.
Shubham Saha1,2, Praveen Singh3, Abhi Dutta1,2
1School of Biosciences and Bioengineering. IIT-Mandi, Mandi, India.
JACC. Asia
|August 24, 2023
Summary
Dilated cardiomyopathy (DCM) involves heart muscle enlargement and dysfunction. This review highlights lipids as potential biomarkers and therapeutic targets for DCM, proposing a lipidomics approach for better diagnosis and prognosis.
Area of Science:
- Cardiovascular Medicine
- Biochemistry
- Molecular Biology
Background:
- Dilated cardiomyopathy (DCM) is a primary cause of heart failure, marked by left ventricular enlargement and impaired myocardial contractility.
- Lipid metabolism is crucial for myocardial energy supply, and disruptions in lipid homeostasis are implicated in DCM pathogenesis.
Purpose of the Study:
- To review the role of various lipids in DCM progression and their potential as biomarkers.
- To elucidate the mechanistic pathways of lipid involvement in DCM and identify cardioprotective lipids.
- To propose a system lipidomics approach for improved DCM diagnosis and prognosis.
Main Methods:
- Literature review summarizing current research on lipids in DCM.
- Analysis of mechanistic pathways involved in lipid metabolism and cardiac function.
- Proposal of a lipidomics-based strategy for patient profiling.
Main Results:
- Specific lipids are identified as potential biomarkers for DCM progression.
- Mechanistic insights into how lipid dysregulation contributes to DCM pathophysiology are discussed.
- Cardioprotective roles of certain lipids in the context of DCM are highlighted.
Conclusions:
- Lipid homeostasis is critical in DCM, with lipids serving as potential diagnostic and prognostic biomarkers.
- Understanding lipid-related mechanisms offers therapeutic avenues for DCM.
- A system lipidomics approach is recommended for enhanced DCM diagnosis and prognosis.
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