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Percutaneous Contrast Echocardiography-guided Intramyocardial Injection and Cell Delivery in a Large Preclinical Model
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Cardiac Interventions in Patients With Active, Advanced Solid and Hematologic Malignancies: JACC: CardioOncology

Darryl P Leong1,2, Filipe Cirne2, Nazanin Aghel2

  • 1The Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada.

JACC. Cardiooncology
|August 24, 2023
PubMed

Insights

Patients with advanced cancer may benefit from invasive cardiac procedures, but evidence is limited. This review provides a framework for deciding on cardiac interventions for cancer patients, considering survival and risks.

Area of Science:

  • Cardiology
  • Oncology
  • Interventional Cardiology

Background:

  • Invasive cardiac interventions are standard for several heart conditions.
  • Clinical trials for these interventions rarely include patients with advanced cancer.
  • Advanced cancer presents a significant mortality risk, complicating treatment decisions.

Purpose of the Study:

  • To review the benefits and risks of invasive cardiac interventions in patients with active, advanced malignancies.
  • To assess contemporary survival expectations for patients with advanced cancers.
  • To develop a framework for guiding clinical recommendations on cardiac interventions in this population.

Main Methods:

  • Literature review of cardiovascular interventions in patients with advanced cancer.
  • Analysis of periprocedural considerations for invasive cardiac procedures.
  • Examination of survival data for various advanced malignancy types.

Main Results:

  • Limited evidence exists on the risks and benefits of cardiac interventions in advanced cancer patients.
  • Survival expectations vary significantly based on cancer type and stage.
  • Periprocedural risks and benefits require careful individualized assessment.

Conclusions:

  • A rational framework is needed to guide decisions on invasive cardiac interventions for advanced cancer patients.
  • Balancing cardiac intervention benefits against cancer prognosis and mortality risk is crucial.
  • Further research is warranted to optimize cardiovascular care for oncology patients.

Keywords:
cancercardio-oncologydual antiplatelet therapyimplantable cardioverter-defibrillatorrevascularizationsurvivorship

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