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Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
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Industrial perspectives for personalized microneedles.

Remmi Danae Baker-Sediako1, Benjamin Richter1, Matthias Blaicher1

  • 1Nanoscribe Gmbh & Co, Hermann-von-Helmholtz-Platz 6, 76344 Eggenstein-Leopoldshafen, Germany.

Beilstein Journal of Nanotechnology
|August 24, 2023
PubMed
Summary

Microneedles offer painless drug delivery, but current designs are not patient-specific. Personalizing microneedle technology could improve drug delivery efficiency and patient healing times.

Keywords:
3D printingmicrofabricationmicroneedlespersonalized medicinetransdermal drug deliverytwo-photon polymerization

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Area of Science:

  • Biomedical Engineering
  • Drug Delivery Systems
  • Materials Science

Background:

  • Microneedles and microneedle arrays are advanced devices for transdermal drug delivery.
  • Additive manufacturing facilitates the creation of novel microneedle designs for research.
  • Current microneedle development often employs a one-size-fits-all approach, neglecting patient variability.

Purpose of the Study:

  • To review current microneedle designs, fabrication techniques, and industrialization strategies.
  • To highlight the limitations of standardized microneedle approaches in transdermal drug delivery.
  • To propose personalized microneedle technology for enhanced patient care.

Main Methods:

  • Literature review of microneedle fabrication and design.
  • Analysis of current industrialization strategies for microneedle devices.
  • Perspective on future directions in microneedle technology.

Main Results:

  • Review of various microneedle designs and microfabrication methods.
  • Identification of a gap in personalized approaches for microneedle-based drug delivery.
  • Discussion of industrialization challenges and opportunities.

Conclusions:

  • Standardized microneedle designs may limit transdermal drug delivery efficiency.
  • Personalized microneedles, tailored to patient demographics, offer potential for improved outcomes.
  • Future research should focus on patient-centric microneedle development for enhanced therapeutic efficacy and reduced healing times.