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TorS - Reframing a rational for type 2 diabetes treatment

Jacob Bar-Tana1

  • 1Hebrew University Medical School, Jerusalem, Israel.

Diabetes/Metabolism Research and Reviews
|August 24, 2023
PubMed

Insights

The mammalian target of rapamycin complex 1 syndrome (Tors) paradigm links numerous diseases to hyperactive mTORC1. This framework may explain current treatment efficacy and guide novel therapeutic strategies for Tors-related conditions.

Area of Science:

  • Biomedical Science
  • Metabolic Disease Research
  • Molecular Medicine

Background:

  • Hyperactivity of the mammalian target of rapamycin complex 1 (mTORC1) is implicated in various pathologies.
  • A cohesive disease entity, termed Tors (mammalian target of rapamycin complex 1 syndrome), is proposed, driven by mTORC1 dysregulation.

Purpose of the Study:

  • To introduce and define the Tors paradigm.
  • To explore the potential of the Tors paradigm in explaining current treatment outcomes.
  • To suggest the Tors paradigm's utility in developing new therapeutic approaches.

Main Methods:

  • Conceptual framework development.
  • Literature review and synthesis of existing research on mTORC1 and associated diseases.
  • Analysis of treatment efficacy in the context of the proposed Tors paradigm.

Main Results:

  • The Tors paradigm encompasses a wide range of diseases including obesity, type 2 diabetic hyperglycemia, cardiovascular diseases, non-alcoholic fatty liver disease, certain cancers, and neurodegeneration.
  • The paradigm offers a potential explanation for why standard treatments for type 2 diabetes (T2D) alleviate both glycaemic and non-glycaemic manifestations of Tors.
  • The Tors paradigm may serve as a foundation for discovering innovative treatments targeting mTORC1 hyperactivity.

Conclusions:

  • The Tors paradigm provides a unifying framework for understanding a spectrum of diseases linked to mTORC1.
  • This paradigm has implications for the efficacy of existing therapies and the development of future treatments for metabolic and other related disorders.
Keywords:
insulinmTORC1syndrome (TorS)metabolic stressmetabolic syndrome (MetS)type 2 diabetes (T2D)

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