[Clinical experience with cefixime in the pediatric field]
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Insights
Cefixime (CFIX) effectively treated pediatric bacterial infections in 25 children, showing good clinical response in most cases. This antibiotic demonstrated a favorable safety profile and palatability, suggesting its utility in pediatric care.
Area of Science:
- Pediatric Infectious Diseases
- Clinical Pharmacology
- Bacteriology
Context:
- Acute bacterial infections are common in children.
- Cefixime is a third-generation cephalosporin antibiotic.
- Evaluating new antibiotic treatments for pediatric populations is crucial.
Purpose:
- To assess the clinical efficacy and safety of oral Cefixime in children with acute bacterial infections.
- To evaluate the bacteriological response to Cefixime treatment.
- To determine the tolerability and acceptance of Cefixime by pediatric patients.
Summary:
- Twenty-five children with infections like tonsillitis, bronchitis, bronchopneumonia, and UTI received oral Cefixime.
- Excellent clinical response was observed in 23 children.
- Bacteriological success was noted in 14 of 16 patients; side effects were minimal (soft stool, eosinophilia in one child each).
Impact:
- Cefixime demonstrates significant clinical effectiveness and a good safety profile for treating various pediatric bacterial infections.
- The antibiotic's palatability suggests good patient compliance in children.
- Findings support Cefixime as a valuable therapeutic option for pediatric bacterial infections.
Abstract:
Cefixime (CFIX) was given orally to 25 children with acute bacterial infections including 13 with acute tonsillitis, 1 with acute tonsillitis and cervical lymphadenitis, 1 with acute bronchitis, 5 with bronchopneumonia and 5 with urinary tract infection. Good to excellent clinical response was obtained in 23, and bacteriological response was obtained in 14 of the 16 children who underwent bacteriological tests. Side effects with soft stool or eosinophilia were observed in 1 child each. The flavor and odor of CFIX appeared to be well accepted by children. Our clinical experience has suggested the usefulness of this antibiotic for the treatment of various bacterial pediatric infections.