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Updated: Jul 18, 2025

Author Spotlight: Investigating Early Events and Long-Term Effects of ACL Injuries for Osteoarthritis Progression
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Author Spotlight: Investigating Early Events and Long-Term Effects of ACL Injuries for Osteoarthritis Progression

Published on: September 29, 2023

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From Inflammation to Resolution: Specialized Pro-resolving Mediators in Posttraumatic Osteoarthritis

Chilan B G Leite1, Gergo Merkely1, Julia F Charles1,2

  • 1Department of Orthopedic Surgery, Brigham and Women's Hospital, Harvard Medical School, 20 Patriot Place Foxboro, Boston, MA, 02035, USA.

Current Osteoporosis Reports
|August 24, 2023
PubMed
Summary

Specialized pro-resolving mediators (SPMs) can help resolve inflammation after anterior cruciate ligament (ACL) injuries. Harnessing SPMs may prevent posttraumatic osteoarthritis (PTOA) and restore joint function.

Keywords:
ACL injuryInflammationPosttraumatic osteoarthritisResolution of inflammationSpecialized pro-resolving mediators

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