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Updated: Jul 18, 2025
Author Spotlight: Advancing Antibiotic Resistance Research Using an Efflux-Deficient Bacterial Strain and a Single-Copy Gene Expression System
Published on: January 5, 2024
Crystallographic structure determination and analysis of a potential short-chain dehydrogenase/reductase (SDR) from
Seyed Mohammad Ghafoori1, Soha Abdollahpour1, Paniz Shirmast2
1School of Dentistry and Medical Sciences, Charles Sturt University, Wagga, Wagga, NSW, Australia.
Abstract:
Bacterial antibiotic resistance remains an ever-increasing worldwide problem, requiring new approaches and enzyme targets. Acinetobacter baumannii is recognised as one of the most significant antibiotic-resistant bacteria, capable of carrying up to 45 different resistance genes, and new drug discovery targets for this organism is an urgent priority. Short-chain dehydrogenase/reductase enzymes are a large protein family with >60,000 members involved in numerous biosynthesis pathways. Here, we determined the structure of an SDR protein from A. baumannii and assessed the putative co-factor comparisons with previously co-crystalised enzymes and cofactors. This study provides a basis for future studies to examine these potential co-factors in vitro.
