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Organoids in COVID-19: can we break the glass ceiling?

Chiu Wang Chau1, Ryohichi Sugimura1,2

  • 1School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, University of Hong Kong, 21 Sassoon Rd, Pokfulam 99077, Hong Kong.

Journal of Leukocyte Biology
|August 24, 2023
PubMed

Insights

Organoids are revolutionizing the study of COVID-19 (Coronavirus Disease 2019), offering new insights into its complex multisystem effects and long-term complications. This review explores organoid technology

Area of Science:

  • Virology and Disease Pathogenesis
  • Biomedical Engineering and Organoid Technology

Background:

  • Coronavirus Disease 2019 (COVID-19), caused by SARS-CoV-2, initially presented as pneumonia but evolved into a multisystem disease with long-term sequelae.
  • Understanding the precise pathogenesis of COVID-19 remains a critical challenge in clinical and scientific research.

Approach:

  • This review highlights the application of organoids, three-dimensional in vitro models derived from stem cells, as an innovative tool for investigating COVID-19.
  • Organoid technology provides a platform to model human organ systems and study SARS-CoV-2 infection dynamics and host responses.

Key Points:

  • Organoids enable the study of SARS-CoV-2 tropism, replication, and induced cellular responses in a human-relevant context.
  • Recent breakthroughs include using organoids to explore viral pathogenesis, test antiviral therapies, and understand long-term COVID-19 complications.
  • The review discusses various organoid models, including lung, gut, and brain organoids, and their specific contributions to COVID-19 research.

Conclusions:

  • Organoids represent a powerful emerging tool for dissecting the complex pathology of COVID-19 and its multisystem manifestations.
  • Despite limitations, organoid models offer significant advantages over traditional cell cultures and animal models for studying SARS-CoV-2 infection.
  • Further development of organoid systems promises to accelerate the discovery of effective treatments and preventative strategies for COVID-19.
Keywords:
COVID-19SARS-CoV-2disease modelingorganoids

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