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Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
Published on: January 3, 2018
Intermolecular Hydrazinative Halogenation of Alkenes with Potassium Halides as Nucleophilic Halogen Sources: Modular
Nan Huang1, Lihao Liao1, Xiaodan Zhao1
1Institute of Organic Chemistry & MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, Guangdong 510006, P. R. China.
Abstract:
An approach for the efficient synthesis of halogenated hydrazines via acid-mediated electrophilic hydrazinative halogenation of alkenes is disclosed. This transformation proceeds with readily available diethyl azodicarboxylate as a hydrazine source and low-cost potassium halides as nucleophilic halogen sources. A series of iodinated, brominated, and chlorinated hydrazines are facilely produced with a wide range of functional groups. The obtained products are good platform molecules. They can be conveniently converted into a variety of valuable phenelzine analogues which are appealing for development of novel drugs treating depression.
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