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Related Experiment Videos

Normal left ventricular function.

J O Parker, R B Case

    Circulation
    |July 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    The normal human heart operates at its peak function, not on the active portion of its curve. Cardiac output in this position is influenced by factors beyond ventricular filling pressure.

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    Area of Science:

    • Cardiology
    • Physiology
    • Human Cardiovascular Function

    Background:

    • The Starling relationship describes ventricular function based on filling pressure.
    • Previous understanding suggested the normal heart operates on the active, ascending portion of its function curve.

    Purpose of the Study:

    • To re-evaluate the Starling relationship in normal, resting, supine humans.
    • To determine the typical operating point of the human ventricle.

    Main Methods:

    • Analysis of ventricular function curves in normal subjects.
    • Measurement of left ventricular end-diastolic pressure and cardiac output.

    Main Results:

    • The peak of the ventricular function curve occurs at a left ventricular end-diastolic pressure of approximately 10 mm Hg.

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  • Normal resting supine individuals operate near this peak, not on the ascending limb.
  • Ventricular pressure-volume dynamics limit response at normal filling pressures.

    • Conclusions:

    • The normal human ventricle, in the resting supine position, functions at its peak, not on the active portion of the Starling curve.
    • Cardiac output is likely regulated by factors other than filling pressure in this state.
    • Ventricular failure shifts the peak of the function curve to higher filling pressures.