Related Experiment Video

Updated: Oct 6, 2026

Cardiac Catheterization in Mice to Measure the Pressure Volume Relationship: Investigating the Bowditch Effect
07:38

Cardiac Catheterization in Mice to Measure the Pressure Volume Relationship: Investigating the Bowditch Effect

Published on: June 14, 2015

[Rate constants of left ventricular relaxation: the effect of inotropic and mechanical factors]

Ts R Orlova, V I Kapel'ko

    Kardiologiia
    |June 1, 1986
    PubMed

    More Related Videos

    Contractility Measurements on Isolated Papillary Muscles for the Investigation of Cardiac Inotropy in Mice06:22

    Contractility Measurements on Isolated Papillary Muscles for the Investigation of Cardiac Inotropy in Mice

    Published on: September 17, 2015

    Mechanical Control of Relaxation Using Intact Cardiac Trabeculae07:51

    Mechanical Control of Relaxation Using Intact Cardiac Trabeculae

    Published on: February 17, 2023

    Related Concept Videos

    Factors Influencing Heart Rate01:30

    Factors Influencing Heart Rate

    The heart rate, or pulse rate, is a vital indicator of cardiovascular health. It reflects the number of times the heart beats per minute. Various physiological and environmental factors influence heart rate, increasing or decreasing cardiac output. Understanding these factors is crucial for assessing heart function and identifying potential health issues.
    Let us explore the significant factors affecting heart rate, including age, body temperature, posture, acute pain, chemical influences,...
    Pathophysiology of Cardiac Performance01:29

    Pathophysiology of Cardiac Performance

    Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
    Heart Failure Drugs: Inotropic Agents01:26

    Heart Failure Drugs: Inotropic Agents

    Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
    Regulation of Stroke Volume01:27

    Regulation of Stroke Volume

    The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
    Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
    Cardiac Output I:Effect of Heart Rate on Cardiac Output01:19

    Cardiac Output I:Effect of Heart Rate on Cardiac Output

    Cardiac Output
    Cardiac output (CO) refers to the total amount of blood ejected by one of the ventricles in liters per minute (L/min). In a resting adult, CO ranges from 5 to 6 L/min, adjusting according to the body's metabolic requirements.
    Effect of Heart Rate on Cardiac Output
    Cardiac output adapts to metabolic demands during stress, physical activity, or illness. The autonomic nervous system regulates heart rate via the sinoatrial node. The parasympathetic nervous system decreases heart rate...
    Cardiac Output II: Effect of Stroke Volume on Cardiac Output01:22

    Cardiac Output II: Effect of Stroke Volume on Cardiac Output

    Cardiac output (CO), the amount of blood the heart pumps per minute, is a parameter in cardiovascular physiology determined by stroke volume and heart rate. Stroke volume, the amount of blood pushed from one of the ventricles per heartbeat, is influenced by preload, afterload, and contractility.
    Preload
    Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...