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Cidofovir in Severe Hypoxemic Adenoviral Pneumonia

Aditi Gupta1, Pooja Khanna1, Arjun Parihar1

  • 1Department of Pediatrics, Amrita Hospital, Mata Amritanandamayi Marg, Sector 88, Faridabad, Haryana, 121002, India.

Indian Journal of Pediatrics
|August 24, 2023
PubMed

Insights

A severe adenovirus pneumonia case in a 16-month-old boy, unresponsive to supportive care, rapidly improved with intravenous cidofovir. This highlights cidofovir as a potential treatment for severe adenovirus infections.

Area of Science:

  • Pediatric Infectious Diseases
  • Virology
  • Critical Care Medicine

Background:

  • Adenovirus infections can cause severe pneumonia in young children.
  • Hypoxemic pneumonia necessitates prompt and effective therapeutic interventions.

Purpose of the Study:

  • To report a case of severe adenovirus pneumonia in an infant.
  • To evaluate the efficacy of intravenous cidofovir in treating severe adenovirus pneumonia.

Main Methods:

  • Clinical case presentation of a 16-month-old boy with severe hypoxemic pneumonia.
  • Diagnostic confirmation of adenovirus via nasopharyngeal aspirate.
  • Administration of intravenous cidofovir for treatment.

Main Results:

  • The patient presented with flu-like symptoms and progressed to severe hypoxemic pneumonia.
  • Adenovirus was identified as the causative pathogen.
  • Intravenous cidofovir administration led to rapid clinical improvement.

Conclusions:

  • Intravenous cidofovir demonstrated significant efficacy in treating severe adenovirus pneumonia in an infant.
  • Cidofovir represents a promising therapeutic option for severe, refractory adenovirus infections in pediatric patients.

Keywords:
AdenovirusCidofovirImmunocompetent childSevere hypoxemic pneumonia

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