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Related Concept Videos

Magnetic Resonance Imaging01:24

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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In vitro Assessment of Aortic Regurgitation Using Four-Dimensional Flow Magnetic Resonance Imaging
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Flow evaluation software for four-dimensional flow MRI: a reliability and validation study.

Barbara Elisabeth Ursula Burkhardt1,2, Christian Johannes Kellenberger3,4, Fraser Maurice Callaghan3,4

  • 1Paediatric Cardiology, Pediatric Heart Center, Department of Surgery, University Children's Hospital Zürich, Steinwiesstrasse 75, 8032, Zurich, Switzerland. barbara.burkhardt@kispi.uzh.ch.

La Radiologia Medica
|August 24, 2023
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Summary
This summary is machine-generated.

Four-dimensional flow MRI (4D flow MRI) accurately quantifies blood flow in congenital heart disease (CHD) patients. Its results align with standard 2D phase-contrast (2D PC) measurements, supporting clinical readiness.

Keywords:
4D flow MRICardiac magnetic resonanceCongenital heart diseaseFlow quantificationHaemodynamicsPhase-contrast magnetic resonance imaging

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Area of Science:

  • Cardiovascular Magnetic Resonance Imaging
  • Medical Imaging Analysis
  • Congenital Heart Disease Diagnostics

Background:

  • Four-dimensional time-resolved phase-contrast cardiovascular magnetic resonance imaging (4D flow MRI) offers comprehensive blood flow quantification.
  • Accurate hemodynamic assessment is vital for managing patients with congenital heart disease (CHD).
  • Comparison with established methods is necessary to validate new imaging techniques.

Purpose of the Study:

  • To evaluate the accuracy of net flow volumes in the aorta and pulmonary arteries using four different 4D flow MRI postprocessing software packages.
  • To compare 4D flow MRI measurements against standard 2D cine phase-contrast (2D PC) measurements in CHD patients.
  • To assess the reliability and reproducibility of 4D flow MRI postprocessing for clinical application.

Main Methods:

  • 47 patients with biventricular CHD underwent 1.5 T 4D flow MRI and 2D PC imaging.
  • Net flow volumes were measured in the ascending aorta and pulmonary arteries using four distinct 4D flow postprocessing software applications.
  • Comparisons were made to offset-corrected 2D PC data, with reliability assessed via Bland-Altman analysis and ICC. Interobserver reproducibility was also evaluated.

Main Results:

  • All four 4D flow MRI software packages demonstrated very good correlation and agreement with 2D PC measurements (ICC ≥ 0.94).
  • Internal flow controls showed excellent linearity for both 2D PC (r ≥ 0.95) and 4D flow MRI (r ≥ 0.94).
  • Interobserver reliability was consistently good across all software vendors (ICC ≥ 0.94).

Conclusions:

  • Hemodynamic data derived from 4D flow MRI in major thoracic arteries, processed by four commercial applications, closely matches routine 2D PC values.
  • The findings indicate that 4D flow MRI-derived data is suitable for clinical implementation in CHD patient management.
  • 4D flow MRI represents a robust tool for blood flow quantification in complex cardiovascular conditions.