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Prognostic value of high-sensitivity C-reactive protein in patients undergoing percutaneous coronary intervention

Le Li1, Shangyu Liu2, Zhuxin Zhang1

  • 1Chinese Academy of Medical Sciences, Peking Union Medical College, National Center for Cardiovascular Diseases, Fu Wai Hospital, Beijing, China.

Cardiovascular Diabetology
|August 24, 2023
PubMed

Insights

High-sensitivity C-reaction protein (hsCRP) elevation predicts major adverse cardiovascular events (MACEs) in patients after percutaneous coronary intervention (PCI). This risk is present regardless of diabetes mellitus status, highlighting hsCRP as a key prognostic biomarker.

Area of Science:

  • Cardiology
  • Biomarkers
  • Inflammation Research

Background:

  • High-sensitivity C-reaction protein (hsCRP) is a marker of inflammation linked to poor cardiovascular outcomes.
  • Percutaneous coronary intervention (PCI) is a common procedure for coronary artery stenosis.
  • The prognostic role of hsCRP in PCI patients, particularly concerning diabetes mellitus (DM), requires further investigation.

Purpose of the Study:

  • To evaluate the prognostic value of hsCRP in patients undergoing PCI.
  • To determine if hsCRP independently predicts major adverse cardiovascular events (MACEs) in patients with or without diabetes mellitus (DM).

Main Methods:

  • A large-scale, prospective cohort study included 8050 patients undergoing PCI.
  • Patients were stratified by hsCRP levels (high > 3 mg/L vs. low ≤ 3 mg/L) and diabetes status (DM vs. non-DM).
  • Major adverse cardiovascular events (MACEs) were assessed over a 3-year follow-up.

Main Results:

  • Elevated hsCRP was significantly associated with an increased risk of MACEs in both diabetic (HR=1.68) and non-diabetic (HR=1.31) patients.
  • The highest incidence of MACEs was observed in patients with high hsCRP and diabetes mellitus.
  • A positive linear relationship was found between hsCRP levels and MACEs.

Conclusions:

  • Elevated hsCRP is an independent risk factor for MACEs in patients undergoing PCI.
  • The prognostic significance of hsCRP in PCI patients is consistent across different glycemic metabolism statuses (diabetic and non-diabetic).
  • hsCRP serves as a crucial biomarker for predicting cardiovascular risk post-PCI.
Abstract

Keywords:
Coronary artery diseaseDiabetes mellitusHigh-sensitivity C-reaction proteinPercutaneous coronary interventionSurvival analysis

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