Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

5.6K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
5.6K
In-vitro Mutagenesis01:16

In-vitro Mutagenesis

14.0K
To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
14.0K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

2.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MYC and RNA Polymerase II Binding Near Transcriptional End Sites Regulate the Expression of Functionally-Related Genes.

bioRxiv : the preprint server for biology·2026
Same author

Incidence of outcomes relevant to vaccine safety monitoring in the general population, after influenza vaccination, and after respiratory infections: a descriptive analysis of four US claims databases, 2022-2023.

Vaccine·2026
Same author

MYCN drives pediatric glioma transformation from neural progenitors and creates distinct therapeutic vulnerabilities.

Cell reports·2026
Same author

Reversible dissociation of mitochondrial Complex V balances anabolic and energy-generating needs in cancer.

iScience·2026
Same author

Hepatoblastoma Cell Lines: Past, Present and Future.

Cells·2025
Same author

Derivation of Genetically Defined Murine Hepatoblastoma Cell Lines with Angiogenic Potential.

Cancers·2025

Related Experiment Video

Updated: Jul 18, 2025

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
09:37

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

8.3K

Lessons in aging from Myc knockout mouse models.

Edward V Prochownik1,2,3,4, Huabo Wang1

  • 1Division of Hematology/Oncology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, United States.

Frontiers in Cell and Developmental Biology
|August 25, 2023
PubMed
Summary

The oncogene MYC

Keywords:
MLXROScancerglycolysismitochondriaprogeriaribosomessenescence

More Related Videos

Forward Genetic Approach to Uncover Stress Resistance Genes in Mice — A High-throughput Screen in ES Cells
15:40

Forward Genetic Approach to Uncover Stress Resistance Genes in Mice — A High-throughput Screen in ES Cells

Published on: November 11, 2015

8.2K
Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism
12:38

Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism

Published on: December 18, 2013

6.1K

Related Experiment Videos

Last Updated: Jul 18, 2025

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
09:37

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging

Published on: July 14, 2016

8.3K
Forward Genetic Approach to Uncover Stress Resistance Genes in Mice — A High-throughput Screen in ES Cells
15:40

Forward Genetic Approach to Uncover Stress Resistance Genes in Mice — A High-throughput Screen in ES Cells

Published on: November 11, 2015

8.2K
Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism
12:38

Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism

Published on: December 18, 2013

6.1K

Area of Science:

  • Oncogenes and Aging Biology
  • Molecular Biology
  • Developmental Biology

Background:

  • The oncogene MYC is crucial for development, but its precise role in normal aging is unknown.
  • MYC deficiency in mice leads to embryonic lethality, hindering studies on its function.
  • Partial MYC deficiency (haploinsufficiency) in mice shows extended lifespan but masks other phenotypes.

Purpose of the Study:

  • To investigate the function of MYC in normal development and aging.
  • To determine the consequences of near-complete MYC loss after birth.
  • To explore the relationship between MYC, aging, and cancer incidence.

Main Methods:

  • Generation of "MycKO" mice with MYC inactivated postnatally.
  • Comparative analysis of lifespan, aging phenotypes, and cancer incidence between MycKO and wild-type mice.
  • Assessment of "Aging Hallmarks" including mitochondrial function, metabolism, and senescence.

Main Results:

  • MycKO mice exhibited significantly longer lifespans than controls.
  • MycKO mice displayed a marked premature aging phenotype, accelerating "Aging Hallmarks".
  • Cancer incidence was dramatically reduced in MycKO mice, suggesting MYC's role in cancer suppression during aging.

Conclusions:

  • MYC inactivation postnatally leads to accelerated aging but reduced cancer, decoupling aging and cancer.
  • Downregulation of MYC and its targets accompanies normal aging in mice and humans.
  • The MycKO mouse model offers a novel platform for studying aging and its link to cancer, distinct from DNA repair models.