Related Experiment Video
Updated: Jun 16, 2026
Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines
Published on: September 21, 2021
Pseudocystic inflammatory demyelinating lesions in multiple sclerosis: A clinical, radiological, and pathological
Florent Cluse1,2, Tanguy Fenouil3, Sandra Vukusic1,4,5,6
1Service de Neurologie, Sclérose en Plaques, Pathologies de la Myéline et Neuro-inflammation, Hôpital Pierre Wertheimer, Hospices Civils de Lyon, Bron, France.
Background:
Pseudocystic inflammatory demyelinating lesions (PIDLs) are poorly described in MS and might represent a diagnostic challenge.
Objectives:
We described the clinical, radiological, pathological, and follow-up characteristics of 13 PIDL in 9 MS patients.
Methods:
We constituted a single-center retrospective case series of PIDLs in MS, defined on MRI as expansive cyst-like lesions, with a fluid-signal content, and a diameter of 1 cm or more.
Results:
PIDL often occurred at first event (56%), were often asymptomatic (69%), and encircled by a hypo-T2 diffusion-restricted rim and a thin ring-like gadolinium enhancement (100%) on magnetic resonance imaging (MRI). Associated typical MS lesions were constant. Biopsies from two PIDLs displayed classical features of active MS, except for unusual edema.
Conclusion:
PIDLs are clinically unremarkable and associated with a good outcome. Their easily recognizable MRI features could help avoid biopsy.
