In Denmark, head injuries are generally managed according to the Scandinavian Neurotrauma Committee Guideline (SNC), which aims to safely reduce head CTs. This review investigates how pre-injury vitamin K-antagonist treatment is associated with adverse outcome in head injury patients, but the significance of other antithrombotics is uncertain. Implementation of S100B in the SNC Guideline has reduced CT usage by approx. 30%. However, S100B could likely be used in a wider array of patients. Despite its usefulness, S100B's popularity is still hampered, likely due to poor practical implementation in Danish emergency rooms.