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Related Concept Videos

Vascular Resistance01:20

Vascular Resistance

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Vascular resistance is a critical concept in understanding blood flow dynamics in the circulatory system. It refers to the resistance that blood encounters as it flows through the blood vessels. This resistance is a key factor in determining blood pressure and cardiac workload.
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The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...
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Computation of Vascular Parameters: Implementing Methodology and Performance Analysis.

Mohamed Yacin Sikkandar1, Sridharan Padmanabhan2, Bobby Mohan2

  • 1Department of Medical Equipment Technology, College of Applied Medical Sciences, Majmaah University, Al Majmaah 11952, Saudi Arabia.

Biosensors
|August 25, 2023
PubMed
Summary
This summary is machine-generated.

A new ultrasound device, CaNVAS, enables continuous, non-invasive monitoring of vascular stiffness and blood pressure. This innovation offers accurate cardiovascular assessment, crucial for managing heart conditions.

Keywords:
acoustic wavesarterial complianceblood pressurepulse wave velocitystiffness index

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A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
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Area of Science:

  • Biomedical Engineering
  • Cardiovascular Research
  • Medical Devices

Background:

  • Accurate in vivo measurement of vascular parameters like pulse wave velocity (PWV), blood pressure (BP), arterial compliance (AC), and stiffness index (SI) is vital for cardiovascular disorder assessment.
  • Traditional methods for BP measurement (cuff-based or invasive catheter) are often not continuous and require manual calculation of other parameters.
  • There is a need for non-invasive, continuous monitoring solutions for vascular health assessment.

Purpose of the Study:

  • To present the feasibility of an automated and accurate in vivo ultrasound sensor for continuous, non-invasive vascular parameter measurement.
  • To introduce the Continuous and Non-Invasive Vascular Stiffness and Arterial Compliance Screener (CaNVAS) device.
  • To validate the CaNVAS device's accuracy and reliability in measuring vascular parameters.

Main Methods:

  • Development of the CaNVAS device utilizing a 5 MHz ultrasound sensor (2.2-10 MHz range) to transmit acoustic waves through arterial walls.
  • Capturing reflected echoes and applying pre-processing techniques to calculate PWV based on frequency shift.
  • Establishing an exponential correlation between CaNVAS-measured PWV and sphygmomanometer-obtained BP values for instantaneous BP computation.

Main Results:

  • The CaNVAS device demonstrated an exponential correlation between measured PWV and BP, enabling instantaneous BP calculation.
  • Validation on 250 subjects showed 95% accuracy and an average coefficient of variation of 12.5% for vascular parameter measurements.
  • The device proved reliable and precise for assessing vascular parameters under pre- and post-exercise conditions.

Conclusions:

  • The CaNVAS device offers a feasible solution for automated, accurate, continuous, and non-invasive in vivo vascular parameter monitoring.
  • This technology can significantly aid in the assessment and management of cardiovascular disorders during surgical procedures and follow-up.
  • CaNVAS provides a reliable and precise tool for evaluating vascular stiffness and arterial compliance.