Smartphone-Based Rigid Endoscopy Device with Hemodynamic Response Imaging and Laser Speckle Contrast Imaging

Area of Science:

• Biomedical Optics
• Medical Imaging
• Point-of-Care Diagnostics

Background:

• Smartphones are increasingly integrated into point-of-care (POC) devices due to advancements in their technology.
• Previous work demonstrated smartphone-based handheld endoscopy using laser speckle contrast imaging (LSCI).

Purpose of the Study:

• To develop a multifunctional handheld endoscope combining smartphone technology with dual-wavelength LSCI.
• To enable simultaneous monitoring of dynamic blood flow and hemoglobin oxygenation (HbO2, Hbr, HbT).

Main Methods:

• Development of a smartphone-integrated dual-wavelength LSCI system.
• Utilizing the smartphone for rapid data acquisition and computation of LSCI data.
• Testing the device with a flow phantom and in vivo rat intestine models during ischemia and reperfusion.

Main Results:

• The device successfully generated blood perfusion maps using LSCI.
• In vivo experiments showed decreased blood flow and HbO2 during ischemia and hyperemia post-reperfusion.
• Demonstrated capability to assess hemodynamic changes in real-time.

Conclusions:

• The smartphone-combined dual-wavelength LSCI endoscope is a promising platform for functional POC endoscopy.
• This technology facilitates understanding of vascular hemodynamics in internal organs.
• Potential applications include diagnosis and treatment monitoring for vascular diseases at the point of care.