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KLVFF Conjugated Curcumin Microemulsion-Based Hydrogel for Transnasal Route: Formulation Development, Optimization,
Rungsinee Phongpradist1, Jutamas Jiaranaikulwanitch1, Kriangkrai Thongkorn2
1Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.
Gels (Basel, Switzerland)
|August 25, 2023
Summary
This study developed a KLVFF conjugated curcumin microemulsion-based hydrogel for transnasal delivery to treat Alzheimer's disease. The optimized hydrogel demonstrated improved mucoadhesion and reduced nasal toxicity, offering a promising drug delivery strategy.
Area of Science:
- Pharmaceutical Sciences
- Neuroscience
- Biomaterials
Background:
- Curcumin shows potential for Alzheimer's disease (AD) treatment but suffers from poor bioavailability and blood-brain barrier penetration.
- Transnasal delivery offers an alternative route, but rapid mucociliary clearance limits drug contact time.
- Developing mucoadhesive systems is crucial for enhancing nasal drug retention and efficacy.
Purpose of the Study:
- To optimize a KLVFF conjugated curcumin microemulsion-based hydrogel (KCMEG) for transnasal administration.
- To improve the mucoadhesive properties of the curcumin formulation for enhanced nasal drug delivery.
- To evaluate the physicochemical characteristics and safety of the optimized KCMEG for potential AD treatment.
Main Methods:
- Utilized a response surface methodology with a central composite design to optimize carbopol 940 concentration and KLVFF conjugated curcumin microemulsion (KCME) percentage.
- Investigated physicochemical properties, anti-cholinesterase, and anti-aggregation activities of KCME.
- Assessed optimized KCMEG for pH, spreadability, mucoadhesion, and ex vivo nasal ciliotoxicity using porcine nasal mucosa.
Main Results:
- The optimization process significantly influenced hardness and adhesiveness (p < 0.05).
- The optimized KCME (70.8 ± 3.4 nm, pH 5.80 ± 0.02) was formulated into KCMEG.
- Optimized KCMEG (2% carbopol 940) exhibited superior in vitro mucoadhesive potential (9.67 ± 0.13 min) and was found to be non-ciliotoxic.
Conclusions:
- Incorporating mucoadhesive agents enhances the retention time of transnasal formulations.
- Optimized KCMEG demonstrates significant potential for improved brain delivery of curcumin.
- KCMEG represents a promising strategy for transnasal treatment of Alzheimer's disease.
Keywords:
AlzheimerKLVFFcentral composite designcurcuminmicroemulsionmicroemulsion-based hydrogeltransnasalMore Related Videos
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