Restoring Adipose Tissue Homeostasis in Response to Aging: Initial Clinical Experience with Profhilo Structura^®

Area of Science:

• Aesthetic Medicine
• Biomaterials Science
• Regenerative Medicine

Background:

• Facial adipose tissue restoration is crucial for aesthetic rejuvenation.
• Existing treatments like crosslinked hyaluronic acid fillers have limitations.
• Novel approaches are needed to address adipose tissue aging effectively.

Purpose of the Study:

• To evaluate the efficacy of a new medical device, Profhilo Structura, for facial adipose tissue restoration.
• To assess the performance of NAHYCO® Hybrid Technology in delivering hybrid molecular-weight hyaluronic acid.
• To determine the safety and patient satisfaction with the novel treatment.

Main Methods:

• A case series involving 22 volunteers (aged 36-60) was conducted.
• Profhilo Structura was injected into superficial facial fat compartments.
• Efficacy was evaluated immediately post-treatment and over a 6-month follow-up period.

Main Results:

• The device demonstrated pseudoplastic behavior and easy extrusion, with lower viscosity than crosslinked HA fillers.
• Immediate increase in soft tissue thickness was observed, persisting for 6 months.
• All subjects reported improved midface aesthetics with no adverse effects.

Conclusions:

• Profhilo Structura effectively restores facial adipose tissue, promoting regeneration and counteracting senescence.
• The treatment provides skin thickening and compaction comparable to crosslinked fillers but avoids crosslinking agents.
• The hybrid hyaluronan technology offers a safe and effective option for natural-looking facial rejuvenation.