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Polymeric Nanoparticles and Nanogels: How Do They Interact with Proteins?
Amirhossein Sadeghi1, Shadi PourEskandar2, Esfandyar Askari3
1Polymer Laboratory, School of Chemistry, College of Science, University of Tehran, Tehran P.O. Box 141556455, Iran.
Gels (Basel, Switzerland)
|August 25, 2023
Summary
Polymeric nanoparticles (PNPs) are promising for biomedicine but require better understanding of their biological identity. This review explores PNP synthesis, protein corona formation, and nanoproteomics for improved clinical translation.
Area of Science:
- Biomedical Engineering
- Materials Science
- Nanotechnology
Background:
- Polymeric nanoparticles (PNPs), nanogels, and solid nanoparticles are synthesized via emulsion methods for biomedical use.
- PNPs offer biocompatibility and biodegradability, controlling interactions with biological systems.
- Despite potential, PNP biological behavior and efficacy lag behind other nanoparticles due to incomplete understanding.
Purpose of the Study:
- To review PNP synthesis and composition to understand protein interactions.
- To explore material and biological factors influencing nanoparticle-protein interactions.
- To discuss PNP-based nanoproteomics models for clinical translation and disease prediction.
Main Methods:
- Investigating conventional PNP synthesis routes and chemical composition.
- Analyzing effects of material and biological parameters on nanoparticle-protein interactions (e.g., hydrophobic bonding, electrostatic interactions).
- Reviewing recent advances in PNP-based models for nanoproteomics.
Main Results:
- Polymeric nanoparticles (PNPs) acquire a protein corona (PC) under physiological conditions.
- Understanding protein corona formation is key to unlocking PNP biomedical potential.
- PNP-based nanoproteomics offers new avenues for nanoparticle clinical translation and early disease detection.
Conclusions:
- Further research into PNP biological identity, particularly protein corona interactions, is crucial.
- Advances in nanoproteomics can accelerate the clinical application of polymeric nanoparticles.
- Polymeric nanoparticles hold significant promise for future biomedical applications and diagnostics.
