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Updated: Jul 18, 2025

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
Published on: June 8, 2020
Using the Multi-Theory Model (MTM) of Health Behavior Change to Explain the Seeking of Stool-Based Tests for
Manoj Sharma1,2, Christopher Johansen1, Kavita Batra3,4
1Department of Social and Behavioral Health, School of Public Health, University of Nevada, Las Vegas, NV 89119, USA.
The Multi-Theory Model (MTM) can effectively predict colorectal cancer (CRC) screening behavior. Interventions promoting stool-based CRC tests can be designed using MTM constructs like participatory dialogue and behavioral confidence.
Area of Science:
- Health Behavior Change
- Cancer Screening
- Public Health Interventions
Background:
- Colorectal cancer (CRC) is a leading cause of cancer deaths globally, despite declining rates in the US.
- Non-invasive stool-based tests are effective for CRC detection, yet current interventions often lack theoretical grounding.
- Disparities in CRC screening persist, highlighting the need for theory-informed approaches.
Purpose of the Study:
- To apply the Multi-Theory Model (MTM) of health behavior change to understand the seeking of stool-based tests for CRC screening.
- To identify key MTM constructs that predict the initiation of CRC screening behaviors in adults aged 45-75.
- To provide a theoretical framework for developing effective interventions to promote CRC screening.
Main Methods:
- A cross-sectional study utilizing an online 57-item questionnaire with established psychometric validity.
- Data collected from a nationwide US sample of 640 adults aged 45-75 years.
- Bivariate, multivariate statistical analyses, and structural equation modeling (SEM) were employed.
Main Results:
- 39.2% of participants reported undergoing stool-based CRC screening.
- For those not screened, MTM subscales (participatory dialogue, behavioral confidence, social environment changes) significantly predicted screening initiation.
- These MTM constructs explained 48% of the variance in screening initiation (adjusted R² = 0.481).
Conclusions:
- The Multi-Theory Model (MTM) offers a robust framework for understanding and promoting stool-based CRC screening.
- Educational, mass media, social media, and clinical interventions can be effectively designed using MTM principles.
- Targeting MTM constructs can help reduce disparities and increase uptake of CRC screening among adults aged 45-75.
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